The antibody
drug conjugates (ADCs) market is projected to grow at a CAGR
of ~9% over the forecast period. Major factors driving growth
include the growing prevalence of cancer, increasing demand for targeted cancer
therapies, advancement in ADC technology, growing investment in R&D for
introducing new antibody-drug conjugates, and increasing approvals by
regulatory bodies such as the FDA and EMA for ADCs. However, the market
encounters certain challenges, including the high cost of development,
stringent regulatory requirements that make the approval process lengthy and
expensive, and increasing competition from emerging therapies.
Antibody-drug conjugates or ADCs are a novel class of highly
potent biopharmaceuticals consisting of a monoclonal antibody chemically linked
to a biologically active drug or cytotoxic compound. These targeted therapies
harness the precise targeting capabilities of antibodies, enabling accurate
differentiation between healthy and cancerous tissues, while delivering the
cell-killing effects of cytotoxic agents. An ideal ADC has:
- A
highly selective monoclonal antibody (mAb) for a tumor-associated antigen
that has restricted or no expression on normal (healthy) cells
- A
potent cytotoxic agent (generally a small molecule drug with high systemic
toxicity) designed to induce target cell death after being internalized in
the tumor cell and released
- A
linker that is stable in circulation, but releases the cytotoxic agent in
target cells
Discover the more details-Download the PDF brochure:
https://meditechinsights.com/antibody-drug-conjugates-market/request-sample/
Growing prevalence of cancer is expected to drive market
growth
Cancer remains one of the leading causes of death globally.
According to GLOBOCAN 2024, in 2022, nearly 20 million new cancer cases were
reported, alongside 9.7 million cancer-related deaths worldwide. Therapeutic
approaches for treating cancer or tumors include chemotherapy, immunotherapy,
radiation therapy, stem cell therapy, laser treatment, hyperthermia, surgery,
and photodynamic therapy, among others. Among these, chemotherapy remains the
primary treatment method.
However, antibody-drug conjugates (ADCs) are rapidly gaining
attention due to their unique capability to combine targeted therapy with
potent cytotoxic agents while leaving healthy cells unharmed. This innovative
approach provides a promising solution for treating various types of cancers,
including those resistant to conventional therapies. To date, 14 ADCs have
received market approval for the treatment of different cancers, with over 200
currently undergoing clinical development. Further, ADCs are revolutionizing
cancer treatment by offering a highly specific mechanism of action, delivering
targeted and effective therapy, and bringing new hope to cancer patients
worldwide.
Technological advancements in antibody-drug conjugate
(ADC) technology to propel market growth
Continuous advancements in the design and development of
antibody-drug conjugates (ADCs) have significantly improved their efficacy and
safety, making them increasingly attractive as treatment options. These
innovations span several critical areas, including antibody engineering, linker
technology, cytotoxic payloads, and manufacturing processes.
One breakthrough is the adoption of site-specific
conjugation techniques, which provide precise control over the drug-to-antibody
ratio, enhancing the consistency and therapeutic performance of ADCs. Another
key innovation is the development of novel linkers that respond to specific
conditions, such as the low pH in the tumor microenvironment, enabling targeted
drug release and reducing off-target toxicity. Additionally, advances in
antibody engineering and selection have led to the creation of antibodies with
enhanced binding specificity, affinity, and pharmacokinetics, further boosting
the potency and effectiveness of ADCs. Improvements in manufacturing
technologies, such as the integration of single-use systems, have addressed
some of the production challenges, increasing efficiency and scalability. As
research in ADCs continues to progress, even more sophisticated and effective
technologies are expected to emerge, broadening the scope of their
applications.
Competitive Landscape Analysis
The global antibody drug conjugates (ADCs) market is marked
by the presence of established and emerging market players such as Takeda
Pharmaceutical Company Ltd.; AstraZeneca PLC; F. Hoffmann-La Roche Ltd.;
Pfizer, Inc.; AbbVie’s; Gilead Sciences, Inc.; Merck & Co.; ADC
Therapeutics SA; Bolt Biotherapeutics; Mersana Therapeutics; and Daiichi
Sankyo Company Ltd.; among others. Some of the key strategies adopted
by market players include new product development, strategic partnerships and
collaborations, and investments.
Unlock key
findings! Fill out a quick inquiry to access a sample report
https://meditechinsights.com/antibody-drug-conjugates-market/request-sample/
Global Antibody Drug Conjugates (ADCs) Market
Segmentation
This report by Medi-Tech Insights provides the size of
the global antibody drug conjugates (ADCs) market at the regional- and
country-level from 2023 to 2030. The report further segments the market based
on product, application, target, and technology.
Market Size & Forecast (2023-2030), By Product, USD
Million
- Kadcyla
- Enhertu
- Adcetris
- Padcev
- Trodelvy
- Polivy
- Others
Market Size & Forecast (2023-2030), By Application,
USD Million
- Breast
Cancer
- Blood
Cancer
- Other
Cancers
Market Size & Forecast (2023-2030), By Target, USD
Million
- HER2
- CD22
- CD30
- Others
Market Size & Forecast (2023-2030), By Technology USD
Million
- Linker
Type
- Cleavable
Linker
- Non-cleavable
Linker
- Linker
less
- Payload
Technology
- MMAE/
Auristatin
- Maytansinoids
- Camptothecin
- Others
Market Size & Forecast (2023-2030), By Region, USD
Million
- North
America
- US
- Canada
- Europe
- UK
- Germany
- Italy
- Spain
- Rest
of Europe
- Asia
Pacific
- China
- India
- Japan
- Rest
of Asia Pacific
- Latin
America
- Middle
East & Africa
About Medi-Tech Insights
Medi-Tech Insights is a healthcare-focused business research
& insights firm. Our clients include Fortune 500 companies, blue-chip
investors & hyper-growth start-ups. We have completed 100+ projects in
Digital Health, Healthcare IT, Medical Technology, Medical Devices & Pharma
Services in the areas of market assessments, due diligence, competitive
intelligence, market sizing and forecasting, pricing analysis &
go-to-market strategy. Our methodology includes rigorous secondary research combined
with deep-dive interviews with industry-leading CXO, VPs, and key demand/supply
side decision-makers.
Contact:
Ruta Halde
Associate, Medi-Tech Insights
+32 498 86 80 79
info@meditechinsights.com
Comments
Post a Comment